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p53 inhibits the upregulation of sirtuin 1 expression induced by c-Myc
Sirtuin 1 (Sirt1), a conserved NAD(+) dependent deacetylase, is a mediator of life span by calorie restriction. However, Sirt1 may paradoxically increase the risk of cancer. Accordingly, the expression level of Sirt1 is selectively elevated in numerous types of cancer cell; however, the mechanisms u...
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| Veröffentlicht in: | Oncol Lett |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
D.A. Spandidos
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5594252/ https://ncbi.nlm.nih.gov/pubmed/28943955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.6661 |
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