Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2

GlyoxalaseI (GLOI) is an enzyme that catalyzes methylglyoxal metabolism. Overexpression of GLOI has been documented in numerous tumor tissues, including colorectal cancer (CRC). The antitumor effects of GLOI depletion have been demonstrated in some types of cancer, but its role in CRC and the mechan...

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Detalhes bibliográficos
Main Authors: Yuan Chen, Lei Fang, Jiali Zhang, Gefei Li, Mengni Ma, Changxi Li, Jianxin Lyu, Qing H. Meng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2017-03-01
Colecção:International Journal of Molecular Sciences
Assuntos:
glyoxalaseI
colorectal cancer
knockdown
signal transducer and activator of transcription 1
p53
Acesso em linha:http://www.mdpi.com/1422-0067/18/3/570
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