Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template switching. Fork reversal is driven...

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Publicado en:Mol Cell
Autores principales: Vujanovic, Marko, Krietsch, Jana, Raso, Maria Chiara, Terraneo, Nastassja, Zellweger, Ralph, Schmid, Jonas A., Taglialatela, Angelo, Huang, Jen-Wei, Holland, Cory L., Zwicky, Katharina, Herrador, Raquel, Jacobs, Heinz, Cortez, David, Ciccia, Alberto, Penengo, Lorenza, Lopes, Massimo
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2017
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Short Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594246/
https://ncbi.nlm.nih.gov/pubmed/28886337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.08.010
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