Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template switching. Fork reversal is driven...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Vujanovic, Marko, Krietsch, Jana, Raso, Maria Chiara, Terraneo, Nastassja, Zellweger, Ralph, Schmid, Jonas A., Taglialatela, Angelo, Huang, Jen-Wei, Holland, Cory L., Zwicky, Katharina, Herrador, Raquel, Jacobs, Heinz, Cortez, David, Ciccia, Alberto, Penengo, Lorenza, Lopes, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
Assuntos:
Short Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594246/
https://ncbi.nlm.nih.gov/pubmed/28886337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.08.010
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