Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template switching. Fork reversal is driven...

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Bibliografski detalji
Izdano u:Mol Cell
Glavni autori: Vujanovic, Marko, Krietsch, Jana, Raso, Maria Chiara, Terraneo, Nastassja, Zellweger, Ralph, Schmid, Jonas A., Taglialatela, Angelo, Huang, Jen-Wei, Holland, Cory L., Zwicky, Katharina, Herrador, Raquel, Jacobs, Heinz, Cortez, David, Ciccia, Alberto, Penengo, Lorenza, Lopes, Massimo
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2017
Teme:
Short Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594246/
https://ncbi.nlm.nih.gov/pubmed/28886337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.08.010
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