NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations

The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. These stalled replication forks then collapse to form one sided double-strand breaks, leading to apoptosis. However, colorectal cancer (CRC) stem cells rapidly repair the stalled/collapsed replication forks...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Narayan, Satya, Jaiswal, Aruna S., Sharma, Ritika, Nawab, Akbar, Duckworth, Lizette Vila, Law, Brian K., Zajac-Kaye, Maria, George, Thomas J., Sharma, Jay, Sharma, Arun K., Hromas, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593639/
https://ncbi.nlm.nih.gov/pubmed/28915668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19778
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