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Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib

The tyrosine kinase inhibitor erlotinib targets the receptor of epidermal growth factor (EGFR) involved in development of hepatocellular carcinoma (HCC). Although inefficient in established HCC, erlotinib has been recently proposed for HCC chemoprevention. Since Cyp3A4 and Cyp1A2 enzymes metabolize...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Rohr-Udilova, Nataliya, Klinglmüller, Florian, Seif, Martha, Hayden, Hubert, Bilban, Martin, Pinter, Matthias, Stolze, Klaus, Sieghart, Wolfgang, Peck-Radosavljevic, Markus, Trauner, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593629/
https://ncbi.nlm.nih.gov/pubmed/28915658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19055
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