Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma

BACKGROUND: Dysregulation and activation of Hedgehog (Hh) signalling may contribute to tumorigenesis, angiogenesis, and metastatic seeding in several solid tumours. OBJECTIVE: We investigated the impact of Hh inhibition on tumour growth and angiogenesis using in-vitro and in-vivo models of hepatocel...

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Detalhes bibliográficos
Main Authors: Pinter, Matthias, Sieghart, Wolfgang, Schmid, Monika, Dauser, Bernhard, Prager, Gerald, Dienes, Hans Peter, Trauner, Michael, Peck-Radosavljevic, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040790/
https://ncbi.nlm.nih.gov/pubmed/24917971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2050640613496605
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