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Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases

The epithelial extracellular membrane-associated serine proteases matriptase, hepsin, and prostasin are proteolytic modifying enzymes of the extracellular domain (ECD) of the epidermal growth factor receptor (EGFR). Matriptase also cleaves the ECD of the vascular endothelial growth factor receptor 2...

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Publicado en:Oncotarget
Autores principales: Chen, Li-Mei, Chai, Karl X.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593577/
https://ncbi.nlm.nih.gov/pubmed/28915606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17009
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