Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer

Cancers acquire multiple somatic mutations that can lead to the generation of immunogenic mutation-induced neoantigens. These neoantigens can be recognized by the host's immune system. However, continuous stimulation of immune cells against tumor antigens can lead to immune cell exhaustion, whi...

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Dettagli Bibliografici
Pubblicato in:Cold Spring Harb Mol Case Stud
Autori principali: Czink, Elena, Kloor, Matthias, Goeppert, Benjamin, Fröhling, Stefan, Uhrig, Sebastian, Weber, Tim F., Meinel, Jörn, Sutter, Christian, Weiss, Karl Heinz, Schirmacher, Peter, Doeberitz, Magnus von Knebel, Jäger, Dirk, Springfeld, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
Soggetti:
Research Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593153/
https://ncbi.nlm.nih.gov/pubmed/28619747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001974
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