Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis

The identification of mutations that enhance antibody affinity while maintaining high antibody specificity and stability is a time-consuming and laborious process. Here, we report an efficient methodology for systematically and rapidly enhancing the affinity of antibody variable domains while maximi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Front Immunol
Hlavní autoři: Tiller, Kathryn E., Chowdhury, Ratul, Li, Tong, Ludwig, Seth D., Sen, Sabyasachi, Maranas, Costas D., Tessier, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591402/
https://ncbi.nlm.nih.gov/pubmed/28928732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00986
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky