LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

The anti-gene strategy is based on sequence-specific recognition of double-strand DNA by triplex forming (TFOs) or DNA strand invading oligonucleotides to modulate gene expression. To be efficient, the oligonucleotides (ONs) should target DNA selectively, with high affinity. Here we combined hybridi...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Pabon-Martinez, Y. Vladimir, Xu, You, Villa, Alessandra, Lundin, Karin E., Geny, Sylvain, Nguyen, Chi-Hung, Pedersen, Erik B., Jørgensen, Per T., Wengel, Jesper, Nilsson, Lennart, Smith, C. I. Edvard, Zain, Rula
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591256/
https://ncbi.nlm.nih.gov/pubmed/28887512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09147-8
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