Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors

S 47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPA-PAM). S 47445 enhanced glutamate’s action at AMPA receptors on human and rat receptors and was inactive at NMDA and kainate receptors. Potentiation did not differ amon...

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Veröffentlicht in:PLoS One
Hauptverfasser: Bretin, Sylvie, Louis, Caroline, Seguin, Laure, Wagner, Stéphanie, Thomas, Jean-Yves, Challal, Sylvie, Rogez, Nathalie, Albinet, Karine, Iop, Fabrice, Villain, Nadège, Bertrand, Sonia, Krazem, Ali, Bérachochéa, Daniel, Billiald, Stéphanie, Tordjman, Charles, Cordi, Alex, Bertrand, Daniel, Lestage, Pierre, Danober, Laurence
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590943/
https://ncbi.nlm.nih.gov/pubmed/28886144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184429
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