Inhibitory effects of a selective Jak2 inhibitor on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT20 cells

PURPOSE: The primary cause of Cushing’s disease is adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. EGFR signaling induces POMC mRNA-transcript levels and ACTH secretion from corticotroph tumors. The Jak–STAT pathway is located downstream of EGFR signaling; therefore, a Jak2 inhibito...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Asari, Yuko, Kageyama, Kazunori, Nakada, Yuki, Tasso, Mizuki, Takayasu, Shinobu, Niioka, Kanako, Ishigame, Noriko, Daimon, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590765/
https://ncbi.nlm.nih.gov/pubmed/28919782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S141345
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