B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis

BACKGROUND: The use of TNF-inhibitors and/or the IL-6 receptor antagonist, tocilizumab, in rheumatoid arthritis (RA) have pleiotropic effects that also involve circulating B-cells. The main goal of this study was to assess the effect of TNF-inhibitors and tocilizumab on B-cell phenotype and gene exp...

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Veröffentlicht in:PLoS One
Hauptverfasser: Moura, Rita A., Quaresma, Cláudia, Vieira, Ana R., Gonçalves, Maria J., Polido-Pereira, Joaquim, Romão, Vasco C., Martins, Nádia, Canhão, Helena, Fonseca, João E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590747/
https://ncbi.nlm.nih.gov/pubmed/28886017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182927
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