Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics

Enzyme prodrug therapy (EPT) enables localized conversion of inert prodrugs to active drugs by enzymes. Performance of EPT necessitates that the enzyme remains active throughout the time frame of the envisioned therapeutic application. β-glucuronidase is an enzyme with historically validated perform...

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Veröffentlicht in:Adv Healthc Mater
Hauptverfasser: Chandrawati, Rona, Olesen, Morten T. J., Marini, Thatiane C. C., Bisra, Gurpal, Guex, Anne Géraldine, de Oliveira, Marcelo G., Zelikin, Alexander N., Stevens, Molly M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590711/
https://ncbi.nlm.nih.gov/pubmed/28699219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201700385
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