Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics

Enzyme prodrug therapy (EPT) enables localized conversion of inert prodrugs to active drugs by enzymes. Performance of EPT necessitates that the enzyme remains active throughout the time frame of the envisioned therapeutic application. β-glucuronidase is an enzyme with historically validated perform...

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Bibliografiska uppgifter
I publikationen:Adv Healthc Mater
Huvudupphovsmän: Chandrawati, Rona, Olesen, Morten T. J., Marini, Thatiane C. C., Bisra, Gurpal, Guex, Anne Géraldine, de Oliveira, Marcelo G., Zelikin, Alexander N., Stevens, Molly M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590711/
https://ncbi.nlm.nih.gov/pubmed/28699219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201700385
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