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Hybrid Approaches to Structural Characterization of Conformational Ensembles of Complex Macromolecular Systems Combining NMR Residual Dipolar Couplings and Solution X-ray Scattering

Solving structures or structural ensembles of large macromolecular systems in solution poses a challenging problem. While NMR provides structural information at atomic resolution, increased spectral complexity, chemical shift overlap, and short transverse relaxation times (associated with slow tumbl...

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Библиографические подробности
Опубликовано в: :Chem Rev
Главные авторы: Venditti, Vincenzo, Egner, Timothy K., Clore, G. Marius
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590664/
https://ncbi.nlm.nih.gov/pubmed/26739383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.5b00592
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