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Global Dynamics and Exchange Kinetics of a Protein on the Surface of Nanoparticles Revealed by Relaxation-Based Solution NMR Spectroscopy

The global motions and exchange kinetics of a model protein, ubiquitin, bound to the surface of negatively charged lipid-based nanoparticles (liposomes) are derived from combined analysis of exchange lifetime broadening arising from binding to nanoparticles of differing size. The relative contributi...

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Библиографические подробности
Опубликовано в: :J Am Chem Soc
Главные авторы: Ceccon, Alberto, Tugarinov, Vitali, Bax, Ad, Clore, G. Marius
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590658/
https://ncbi.nlm.nih.gov/pubmed/27111298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02654
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