(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1

BACKGROUND: Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes in patients with NSCLC as a number of oncogenic drivers have been found. Crizot...

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Bibliografski detalji
Izdano u:J Exp Clin Cancer Res
Glavni autori: Dai, Xuanxuan, Guo, Guilong, Zou, Peng, Cui, Ri, Chen, Weiqian, Chen, Xi, Yin, Changtian, He, Wei, Vinothkumar, Rajamanickam, Yang, Fan, Zhang, Xiaohua, Liang, Guang
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590185/
https://ncbi.nlm.nih.gov/pubmed/28882182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0584-3
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