Curcuminoid EF24 enhances the anti‐tumour activity of Akt inhibitor MK‐2206 through ROS‐mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer

BACKGROUND AND PURPOSE: Gastric cancer is one of the leading causes of morbidity and mortality worldwide. Akt is an anti‐apoptotic kinase that plays a dynamic role in cell survival and is implicated in the pathogenesis of gastric cancer. MK‐2206, the first allosteric inhibitor of Akt, is in clinical...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Chen, Xi, Dai, Xuanxuan, Zou, Peng, Chen, Weiqian, Rajamanickam, Vinothkumar, Feng, Chen, Zhuge, Weishan, Qiu, Chenyu, Ye, Qingqing, Zhang, Xiaohua, Liang, Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406301/
https://ncbi.nlm.nih.gov/pubmed/28255993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13765
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