Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model

BACKGROUND: Alexander disease (AxD) is an astrogliopathy that predominantly affects the white matter of the central nervous system (CNS), and is caused by a mutation in the gene encoding the glial fibrillary acidic protein (GFAP), an intermediate filament primarily expressed in astrocytes and ependy...

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Publicado en:BMC Neurol
Autores principales: Lee, So-Hyun, Nam, Tai-Seung, Kim, Kun-Hee, Kim, Jin Hee, Yoon, Woong, Heo, Suk-Hee, Kim, Min Jung, Shin, Boo Ahn, Perng, Ming-Der, Choy, Hyon E., Jo, Jihoon, Kim, Myeong-Kyu, Choi, Seok-Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590178/
https://ncbi.nlm.nih.gov/pubmed/28882119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-017-0938-7
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