Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway

Methylglyoxal (MG), an extremely reactive glucose metabolite, exhibits antitumor activity. Glyoxalase I (GLOI), which catalyzes MG metabolism, is associated with the progression of human malignancies. While the roles of MG or GLOI have been demonstrated in some types of cancer, their effects in colo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chen, Yuan, Fang, Lei, Li, Gefei, Zhang, Jiali, Li, Changxi, Ma, Mengni, Guan, Chen, Bai, Fumao, Lyu, Jianxin, Meng, Qing H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589625/
https://ncbi.nlm.nih.gov/pubmed/28903386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18601
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