Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma

Cancer-induced bone pain (CIBP) is common in patients with bone metastases (BM), significantly impairing quality of life. The current treatments for CIBP are limited since they are often ineffective. Local acidosis derived from glycolytic carcinoma and tumor-induced osteolysis is only barely explore...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Di Pompo, Gemma, Lemma, Silvia, Canti, Lorenzo, Rucci, Nadia, Ponzetti, Marco, Errani, Costantino, Donati, Davide Maria, Russell, Shonagh, Gillies, Robert, Chano, Tokuhiro, Baldini, Nicola, Avnet, Sofia
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589596/
https://ncbi.nlm.nih.gov/pubmed/28903357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17091
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