Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma

Cancer-induced bone pain (CIBP) is common in patients with bone metastases (BM), significantly impairing quality of life. The current treatments for CIBP are limited since they are often ineffective. Local acidosis derived from glycolytic carcinoma and tumor-induced osteolysis is only barely explore...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Di Pompo, Gemma, Lemma, Silvia, Canti, Lorenzo, Rucci, Nadia, Ponzetti, Marco, Errani, Costantino, Donati, Davide Maria, Russell, Shonagh, Gillies, Robert, Chano, Tokuhiro, Baldini, Nicola, Avnet, Sofia
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589596/
https://ncbi.nlm.nih.gov/pubmed/28903357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17091
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