The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways

Gpbar1 (TGR5), a G-protein-coupled bile acid membrane receptor, is well known for its roles in regulation of glucose metabolism and energy homeostasis. In the current work, we found that TGR5 activation by its ligand suppressed lipopolysaccharide (LPS)-induced proinflammatory gene expression in wild...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Su, Jia, Zhang, Qiqi, Qi, Hui, Wu, Linlin, Li, Yuanqiang, Yu, Donna, Huang, Wendong, Chen, Wei-Dong, Wang, Yan-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589588/
https://ncbi.nlm.nih.gov/pubmed/28903349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17533
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