The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well-known for its roles in regulation of energy homeostasis and glucose metabolism. Here, we show that mice lacking TGR5 were much more susceptible to lipopolysaccharide (LPS)-induced acute gastric inflammation than wild-type (WT) mice and TGR5...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Guo, Cong, Qi, Hui, Yu, Yingjie, Zhang, Qiqi, Su, Jia, Yu, Donna, Huang, Wendong, Chen, Wei-Dong, Wang, Yan-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675858/
https://ncbi.nlm.nih.gov/pubmed/26696888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00287
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