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The deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. We recently reported that TGR5 activation inhibits nuclear factor κB (NF-κB)-mediated inflammation. Here we show that TGR5 deficiency enhances chemically-induce...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Wei-Dong, Yu, Donna, Forman, Barry M., Huang, Wendong, Wang, Yan-Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745510/
https://ncbi.nlm.nih.gov/pubmed/22911633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26019
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