MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia

The SET (I2PP2A) oncoprotein is a potent inhibitor of protein phosphatase 2A (PP2A) that regulates many cell processes and important signaling pathways. Despite the importance of SET overexpression and its prognostic impact in both hematologic and solid tumors, little is known about the mechanisms i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Pippa, Raffaella, Dominguez, Ana, Malumbres, Raquel, Endo, Akinori, Arriazu, Elena, Marcotegui, Nerea, Guruceaga, Elizabeth, Odero, María D.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589557/
https://ncbi.nlm.nih.gov/pubmed/28903318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9840
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