Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase

We explored the utility of targeting anaplastic lymphoma kinase (ALK), a cell surface receptor overexpressed on pediatric solid tumors, using chimeric antigen receptor (CAR)-based immunotherapy. T cells expressing a CAR incorporating the single-chain variable fragment sequence of the ALK48 mAb linke...

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Pubblicato in:Mol Ther
Autori principali: Walker, Alec J., Majzner, Robbie G., Zhang, Ling, Wanhainen, Kelsey, Long, Adrienne H., Nguyen, Sang M., Lopomo, Paola, Vigny, Marc, Fry, Terry J., Orentas, Rimas J., Mackall, Crystal L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589087/
https://ncbi.nlm.nih.gov/pubmed/28676342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.008
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