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Machine learning reveals a non‐canonical mode of peptide binding to MHC class II molecules

MHC class II molecules play a fundamental role in the cellular immune system: they load short peptide fragments derived from extracellular proteins and present them on the cell surface. It is currently thought that the peptide binds lying more or less flat in the MHC groove, with a fixed distance of...

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Vydáno v:Immunology
Hlavní autoři: Andreatta, Massimo, Jurtz, Vanessa I., Kaever, Thomas, Sette, Alessandro, Peters, Bjoern, Nielsen, Morten
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588850/
https://ncbi.nlm.nih.gov/pubmed/28542831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12763
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