Membrane‐bound Dickkopf‐1 in Foxp3(+) regulatory T cells suppresses T‐cell‐mediated autoimmune colitis

Induction of tolerance is a key mechanism to maintain or to restore immunological homeostasis. Here we show that Foxp3(+) regulatory T (Treg) cells use Dickkopf‐1 (DKK‐1) to regulate T‐cell‐mediated tolerance in the T‐cell‐mediated autoimmune colitis model. Treg cells from DKK‐1 hypomorphic doubleri...

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Xehetasun bibliografikoak
Argitaratua izan da:Immunology
Egile Nagusiak: Chae, Wook‐Jin, Park, Jong‐Hyun, Henegariu, Octavian, Yilmaz, Saliha, Hao, Liming, Bothwell, Alfred L. M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588763/
https://ncbi.nlm.nih.gov/pubmed/28556921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12766
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