Smad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis

Both environmental cues and intracellular bioenergetic states profoundly affect intracellular pH (pHi). How a cell responds to pHi changes to maintain bioenergetic homeostasis remains elusive. Here we show that Smad5, a well-characterized downstream component of bone morphogenetic protein (BMP) sign...

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Gepubliceerd in:Cell Res
Hoofdauteurs: Fang, Yujiang, Liu, Zhongliang, Chen, Zhenyu, Xu, Xiangjie, Xiao, Mengtao, Yu, Yanyan, Zhang, Yuanyuan, Zhang, Xiaobai, Du, Yanhua, Jiang, Cizhong, Zhao, Yuzheng, Wang, Yiran, Fan, Beibei, Terheyden-Keighley, Daniel, Liu, Yang, Shi, Lei, Hui, Yi, Zhang, Xin, Zhang, Bowen, Feng, Hexi, Ma, Lin, Zhang, Quanbin, Jin, Guohua, Yang, Yi, Xiang, Bin, Liu, Ling, Zhang, Xiaoqing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587853/
https://ncbi.nlm.nih.gov/pubmed/28675158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.85
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