Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma

Aberrant metabolism in hexosamine biosynthetic pathway (HBP) has been observed in several cancers, affecting cellular signaling and tumor progression. However, the role of O-GlcNAcylation, a post-translational modification through HBP flux, in apoptosis remains unclear. Here, we found that hyper-O-G...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Luanpitpong, Sudjit, Angsutararux, Paweorn, Samart, Parinya, Chanthra, Nawin, Chanvorachote, Pithi, Issaragrisil, Surapol
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587763/
https://ncbi.nlm.nih.gov/pubmed/28878262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10886-x
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