Metabolic sensor O‐GlcNAcylation regulates megakaryopoiesis and thrombopoiesis through c‐Myc stabilization and integrin perturbation

Metabolic state of hematopoietic stem cells (HSCs) is an important regulator of self‐renewal and lineage‐specific differentiation. Posttranslational modification of proteins via O‐GlcNAcylation is an ideal metabolic sensor, but how it contributes to megakaryopoiesis and thrombopoiesis remains unknow...

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Bibliographic Details
Published in:Stem Cells
Main Authors: Luanpitpong, Sudjit, Poohadsuan, Jirarat, Klaihmon, Phatchanat, Kang, Xing, Tangkiettrakul, Kantpitchar, Issaragrisil, Surapol
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Inc. 2021
Subjects:
Tissue‐specific Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248081/
https://ncbi.nlm.nih.gov/pubmed/33544938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3349
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