Metabolic sensor O‐GlcNAcylation regulates megakaryopoiesis and thrombopoiesis through c‐Myc stabilization and integrin perturbation

Metabolic state of hematopoietic stem cells (HSCs) is an important regulator of self‐renewal and lineage‐specific differentiation. Posttranslational modification of proteins via O‐GlcNAcylation is an ideal metabolic sensor, but how it contributes to megakaryopoiesis and thrombopoiesis remains unknow...

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Dettagli Bibliografici
Pubblicato in:Stem Cells
Autori principali: Luanpitpong, Sudjit, Poohadsuan, Jirarat, Klaihmon, Phatchanat, Kang, Xing, Tangkiettrakul, Kantpitchar, Issaragrisil, Surapol
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2021
Soggetti:
Tissue‐specific Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248081/
https://ncbi.nlm.nih.gov/pubmed/33544938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3349
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