Metabolic sensor O‐GlcNAcylation regulates megakaryopoiesis and thrombopoiesis through c‐Myc stabilization and integrin perturbation

Metabolic state of hematopoietic stem cells (HSCs) is an important regulator of self‐renewal and lineage‐specific differentiation. Posttranslational modification of proteins via O‐GlcNAcylation is an ideal metabolic sensor, but how it contributes to megakaryopoiesis and thrombopoiesis remains unknow...

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Détails bibliographiques
Publié dans:Stem Cells
Auteurs principaux: Luanpitpong, Sudjit, Poohadsuan, Jirarat, Klaihmon, Phatchanat, Kang, Xing, Tangkiettrakul, Kantpitchar, Issaragrisil, Surapol
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Inc. 2021
Sujets:
Tissue‐specific Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248081/
https://ncbi.nlm.nih.gov/pubmed/33544938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3349
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