Metabolic sensor O‐GlcNAcylation regulates megakaryopoiesis and thrombopoiesis through c‐Myc stabilization and integrin perturbation

Metabolic state of hematopoietic stem cells (HSCs) is an important regulator of self‐renewal and lineage‐specific differentiation. Posttranslational modification of proteins via O‐GlcNAcylation is an ideal metabolic sensor, but how it contributes to megakaryopoiesis and thrombopoiesis remains unknow...

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Bibliografski detalji
Izdano u:Stem Cells
Glavni autori: Luanpitpong, Sudjit, Poohadsuan, Jirarat, Klaihmon, Phatchanat, Kang, Xing, Tangkiettrakul, Kantpitchar, Issaragrisil, Surapol
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2021
Teme:
Tissue‐specific Stem Cells
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248081/
https://ncbi.nlm.nih.gov/pubmed/33544938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3349
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