Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing. Here, we show that upregulating Drp1—a Dynamin-related protein that promotes mitochondrial fission—in midlife, prolongs Drosophila...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Rana, Anil, Oliveira, Matheus P., Khamoui, Andy V., Aparicio, Ricardo, Rera, Michael, Rossiter, Harry B., Walker, David W.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587646/
https://ncbi.nlm.nih.gov/pubmed/28878259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00525-4
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