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Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
Aberrant protein aggregation and mitochondrial dysfunction have each been linked to aging and a number of age-onset neurodegenerative disorders, including Parkinson disease. Loss-of-function mutations in parkin, an E3 ubiquitin ligase that functions to promote the ubiquitin–proteasome system of prot...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3666724/ https://ncbi.nlm.nih.gov/pubmed/23650379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216197110 |
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