Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer

The aryl hydrocarbon receptor (AHR) plays crucial roles in inflammation, metabolic disorder, and cancer. However, the molecular mechanisms regulating AHR expression remain unknown. Here, we found that an orphan nuclear NR2E3 maintains AHR expression, and forms an active transcriptional complex with...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Khanal, Tilak, Choi, Kwangmin, Leung, Yuet-Kin, Wang, Jiang, Kim, Dasom, Janakiram, Vinothini, Cho, Sung-Gook, Puga, Alvaro, Ho, Shuk-Mei, Kim, Kyounghyun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587550/
https://ncbi.nlm.nih.gov/pubmed/28878246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11106-2
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