Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapy

Nucleotide excision repair (NER) plays a vital role in platinum-induced DNA damage during chemotherapy. We hypothesize that regulatory single nucleotide polymorphisms (rSNPs) of the core NER genes modulate clinical outcome of patients with advanced non-small cell lung cancer (NSCLC) treated with pla...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhang, Ruoxin, Jia, Ming, Xue, Huijing, Xu, Yuan, Wang, Mengyun, Zhu, Meiling, Sun, Menghong, Chang, Jianhua, Wei, Qingyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587538/
https://ncbi.nlm.nih.gov/pubmed/28878296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10800-5
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