Estradiol as a Targeted, Late-Line Therapy in Metastatic Breast Cancer with Estrogen Receptor Amplification

Estradiol is a major regulator of growth for the subset of breast cancers that express the estrogen receptor (ER, ESR1). Strategies to block ER action, via reduction of estradiol or direct inhibition of ER, have shown major success in the prevention and treatment of breast cancer. However, most ER-p...

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Bibliographic Details
Published in:Cureus
Main Authors: Kota, Karthik, Brufsky, Adam, Oesterreich, Steffi, Lee, Adrian
Format: Artigo
Language:Inglês
Published: Cureus 2017
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587405/
https://ncbi.nlm.nih.gov/pubmed/28924522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7759/cureus.1434
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