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2B4-mediated coinhibition of CD4(+) T cells underlies mortality in experimental sepsis
Sepsis is a leading cause of death in the U.S. but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on NK cells and memory CD8(+) T cells that has been shown to regulate T cell function in mod...
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| Publicado en: | J Immunol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587400/ https://ncbi.nlm.nih.gov/pubmed/28768726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700375 |
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