2B4-mediated coinhibition of CD4(+) T cells underlies mortality in experimental sepsis

Sepsis is a leading cause of death in the U.S. but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on NK cells and memory CD8(+) T cells that has been shown to regulate T cell function in mod...

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Udgivet i:J Immunol
Main Authors: Chen, Ching-wen, Mittal, Rohit, Klingensmith, Nathan J., Burd, Eileen M., Terhorst, Cox, Martin, Greg S., Coopersmith, Craig M., Ford, Mandy L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587400/
https://ncbi.nlm.nih.gov/pubmed/28768726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700375
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