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Involvement of arginine 878 together with Ca(2+) in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues
Aminopeptidase A (APA) is a membrane-bound zinc metalloprotease cleaving, in the brain, the N-terminal aspartyl residue of angiotensin II to generate angiotensin III, which exerts a tonic stimulatory effect on the control of blood pressure in hypertensive animals. Using a refined APA structure deriv...
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| Publicado en: | PLoS One |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587309/ https://ncbi.nlm.nih.gov/pubmed/28877217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184237 |
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