Involvement of arginine 878 together with Ca(2+) in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues

Aminopeptidase A (APA) is a membrane-bound zinc metalloprotease cleaving, in the brain, the N-terminal aspartyl residue of angiotensin II to generate angiotensin III, which exerts a tonic stimulatory effect on the control of blood pressure in hypertensive animals. Using a refined APA structure deriv...

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Bibliographic Details
Published in:PLoS One
Main Authors: Couvineau, Pierre, de Almeida, Hugo, Maigret, Bernard, Llorens-Cortes, Catherine, Iturrioz, Xavier
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587309/
https://ncbi.nlm.nih.gov/pubmed/28877217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184237
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