Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

BACKGROUND: Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729) with the primary objectives to determine the appropriate dose for Phase II studies, characterize ph...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Onco Targets Ther
Main Authors: Creelan, Ben C, Gabrilovich, Dmitry I, Gray, Jhanelle E, Williams, Charles C, Tanvetyanon, Tawee, Haura, Eric B, Weber, Jeffrey S, Gibney, Geoffrey T, Markowitz, Joseph, Proksch, Joel W, Reisman, Scott A, McKee, Mark D, Chin, Melanie P, Meyer, Colin J, Antonia, Scott J
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2017
Fag:
Clinical Trial Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587199/
https://ncbi.nlm.nih.gov/pubmed/28919776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S136992
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker