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Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
BACKGROUND: Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being evaluated in patients with Friedreich’s ataxia. METH...
Enregistré dans:
| Publié dans: | Drug Des Devel Ther |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Dove Medical Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6475100/ https://ncbi.nlm.nih.gov/pubmed/31118567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S193889 |
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