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The hybridization-stabilization assay: a solution-based isothermal method for rapid screening and determination of sequence preference of ligands that bind to duplexed nucleic acids

The gene-to-drug quest will be most directly served by the discovery and development of small molecules that bind to nucleic acids and modulate gene expression at the level of transcription and/or inhibit replication of infectious agents. Full realization of this potential will require implementatio...

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Autores principales: Gonzalez, Carolyn, Moore, Megan, Ribeiro, Sofia, Schmitz, Uli, Schroth, Gary P., Turin, Lisa, Bruice, Thomas W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC55869/
https://ncbi.nlm.nih.gov/pubmed/11504893
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