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Matrix Metalloproteinase Inhibitor COL-3 Prevents the Development of Paclitaxel-Induced Hyperalgesia in Mice

OBJECTIVE: To study the potential of chemically modified tetracycline-3 (COL-3), a potent matrix metalloproteinase (MMP) inhibitor, to protect against the development of paclitaxel-induced painful neuropathy and its immunomodulatory effects. MATERIALS AND METHODS: The reaction latency to thermal sti...

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Publicat a:Med Princ Pract
Autors principals: Parvathy, Subramanian S., Masocha, Willias
Format: Artigo
Idioma:Inglês
Publicat: S. Karger AG 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586713/
https://ncbi.nlm.nih.gov/pubmed/22907189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000341710
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