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Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer
BACKGROUND: Compromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity‐based pathology in heart disease is just beginning. The molecular...
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| 出版年: | J Am Heart Assoc |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5586456/ https://ncbi.nlm.nih.gov/pubmed/28862927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006182 |
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