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C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-catalyzed C–H Activation

Herein, we report a Rh(I)/bisphosphine/K(3)PO(4) catalytic system allowing for the first time the selective branched C–H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles...

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Dades bibliogràfiques
Publicat a:J Org Chem
Autors principals: Tran, Gaël, Confair, Danielle, Hesp, Kevin D., Mascitti, Vincent, Ellman, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585739/
https://ncbi.nlm.nih.gov/pubmed/28828857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b01723
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