Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity

Butyrylcholinesterase (BChE) is an enzyme with broad substrate and ligand specificities and may function as a generalized bioscavenger by binding and/or hydrolyzing various xenobiotic agents and toxicants, many of which target the central and peripheral nervous systems. Variants of BChE were rationa...

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Udgivet i:Sci Rep
Main Authors: Larrimore, Katherine E., Kazan, I. Can, Kannan, Latha, Kendle, R. Player, Jamal, Tameem, Barcus, Matthew, Bolia, Ashini, Brimijoin, Stephen, Zhan, Chang-Guo, Ozkan, S. Banu, Mor, Tsafrir S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585256/
https://ncbi.nlm.nih.gov/pubmed/28874829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10571-z
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