T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection

Intracerebral Theiler’s murine encephalomyelitis virus (TMEV) infection in mice induces inflammatory demyelination in the central nervous system. Although C57BL/6 mice normally resistant to TMEV infection with viral clearance, we have previously demonstrated that RORγt-transgenic (tg) C57BL/6 mice,...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Sato, Fumitaka, Kawai, Eiichiro, Martinez, Nicholas E., Omura, Seiichi, Park, Ah-Mee, Takahashi, Satoru, Yoh, Keigyou, Tsunoda, Ikuo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585213/
https://ncbi.nlm.nih.gov/pubmed/28874814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10980-0
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